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<p>Preface xxi</p> <p>Acknowledgements xxvii</p> <p><b>Part I Virology and Viral Disease 1</b></p> <p>Chapter 1 Introduction – The Impact of Viruses on Our View of Life 3</p> <p>Chapter 2 An Outline of Virus Replication and Viral Pathogenesis 15</p> <p>Chapter 3 Virus Disease in Populations and Individual Animals 27</p> <p>Chapter 4 Patterns of Some Viral Diseases of Humans 43</p> <p><b>Part II Basic Properties of Viruses and Virus–cell Interaction 65</b></p> <p>Chapter 5 Virus Structure and Classification 67</p> <p>Chapter 6 The Beginning and End of the Virus Replication Cycle 85</p> <p>Chapter 7 The Innate Immune Response: Early Defense Against Pathogens 105</p> <p>Chapter 8 Strategies to Protect Against and Combat Viral Infection 131</p> <p><b>Part III Working with Virus 153</b></p> <p>Chapter 9 Visualization and Enumeration of Virus Particles 155</p> <p>Chapter 10 Replicating and Measuring Biological Activity of Viruses 163</p> <p>Chapter 11 Physical and Chemical Manipulation of the Structural Components of Viruses 181</p> <p>Chapter 12 Characterization of Viral Products Expressed in the Infected Cell 197</p> <p>Chapter 13 Viruses Use Cellular Processes to Express their Genetic Information 217</p> <p><b>Part IV Replication Patterns of Specific Viruses 245</b></p> <p>Chapter 14 Replication of Positive‐Sense RNA Viruses 247</p> <p>Chapter 15 Replication Strategies of RNA Viruses Requiring RNA‐directed mRNA Transcription as the First Step in Viral Gene Expression 277</p> <p>Chapter 16 Replication Strategies of Small and Medium‐sized DNA Viruses 307</p> <p>Chapter 17 Replication of Some Nuclear‐replicating Eukaryotic DNA Viruses with Large Genomes 335</p> <p>Chapter 18 Replication of Cytoplasmic DNA Viruses and “Large” Bacteriophages 363</p> <p>Chapter 19 Retroviruses: Converting RNA to DNA 385</p> <p>Chapter 20 Human Immunodeficiency Virus Type 1 (HIV‐1) and Related Lentiviruses 403</p> <p>Chapter 21 Hepadnaviruses: Variations on the Retrovirus Theme 415</p> <p><b>Part V Molecular Genetics of Viruses 437</b></p> <p>Chapter 22 The Molecular Genetics of Viruses 439</p> <p>Chapter 23 Molecular Pathogenesis 467</p> <p>Chapter 24 Viral Bioinformatics 477</p> <p>Chapter 25 Viruses and the Future – Problems and Promises 489</p> <p>Appendix – Resource Center 503</p> <p>Technical Glossary 509</p> <p>Index 533</p>

<b>MARTINEZ J. HEWLETT</b> is Professor Emeritus in the Department of Molecular and Cellular Biology at the University of Arizona.<br /><br /><b><b>DAVID CAMERINI</b> </b>is Assistant Professor in the Department of Molecular Biology and Biochemistry at the University of California Irvine.<b><br /><br />DAVID C. BLOOM</b> is Associate Professor in the Department of Molecular Genetics and Microbiology at University of Florida.

<p><b>The foundational textbook on the study of virology</b></p><p><i>Basic Virology, 4^th Edition</i> cements this series’ position as the leading introductory virology textbook in the world. It’s easily read style, outstanding figures, and comprehensive coverage of fundamental topics in virology all account for its immense popularity.</p><p>This undergraduate-accessible book covers all the foundational topics in virology, including: </p><ul><li>The basics of virology</li><li>Virological techniques</li><li>Molecular biology</li><li>Pathogenesis of human viral disease</li></ul><p>The fourth edition includes new information on hepatitis C virus, influenza virus, HIV, Ebola virus, as well as the coronaviruses that cause SARS, MERS and COVID-19. New virological techniques including bioinformatics and advances in viral therapies for human disease are also explored in-depth. The book also includes entirely new sections on metapneumoviruses, dengue virus, and the chikungunya virus.</p><p>A full discussion of antiviral therapies, focusing particularly on combination therapies for HCV and HBV is also included. The sections on innate, intrinsic and adaptive immune responses to viral infections have also been updated.</p>

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