Details

Fc Mediated Activity of Antibodies


Fc Mediated Activity of Antibodies

Structural and Functional Diversity
Current Topics in Microbiology and Immunology, Band 423

von: Jeffrey V. Ravetch, Falk Nimmerjahn

CHF 100.50

Verlag: Springer
Format: PDF
Veröffentl.: 03.09.2019
ISBN/EAN: 9783030310530
Sprache: englisch

Dieses eBook enthält ein Wasserzeichen.

Beschreibungen

<p>This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.</p><p></p>
<p>IgG Fc receptors: evolutionary considerations.- Role of FcgRs in Antibody Based Cancer Therapy.- Anti-inflammatory Activity of IgG-Fc.- IgG Fc glycosylation in human immunity.- IgE Glycosylation in Health and Disease.- Immune Complex Vaccination.- Fc receptors in anti-microbial protection.</p><p></p>
<p>Jeffrey V. Ravetch</p><p>Theresa and Eugene M. Lang Professor</p><p>Department Leonard Wagner Laboratory of Molecular Genetics and Immunology</p><p>Rockefeller University</p><p>1230 York Avenue, Box 98</p><p>New York, NY 10021, USA</p><p>ravetch@mail.rockefeller.edu</p><p><br></p><p>Falk Nimmerjahn</p><p>Professor for Immunology and Genetics</p><p>Chairman of the Institute of Genetics</p><p>Head of the Department of Biology</p><p>Department of Biology</p><p>University of Erlangen-Nuernberg</p><p>Erwin-Rommelstr. 3</p>91058 Erlangen, Germany<p></p><p>falk.nimmerjahn@fau.de</p><div><br></div>
This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.
Examines the structural diversity of the Fc domain for IgG and IgE Explores the role of Fc receptors in the context of infectious, autoimmune, and neoplastic disorders Provides comprehensive information on Fc receptor pathways as an essential part of the immune response
<div><div><br></div></div>

Diese Produkte könnten Sie auch interessieren:

Neural Engineering
Neural Engineering
von: Bin He
PDF ebook
CHF 147.00
Glutamate Receptors in Peripheral Tissue
Glutamate Receptors in Peripheral Tissue
von: Santokh Gill, Olga Pulido
PDF ebook
CHF 236.00
Neural Cell Behavior and Fuzzy Logic
Neural Cell Behavior and Fuzzy Logic
von: Uziel Sandler, Lev Tsitolovsky
PDF ebook
CHF 177.00